BAIT
BST2
CD317, TETHERIN
bone marrow stromal cell antigen 2
GO Process (19)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- defense response to virus [IDA]
- humoral immune response [TAS]
- innate immune response [IDA]
- multicellular organismal development [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of intracellular transport of viral material [IDA]
- negative regulation of plasmacytoid dendritic cell cytokine production [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of actin cytoskeleton organization [ISS]
- response to interferon-alpha [ISS]
- response to interferon-beta [ISS]
- response to interferon-gamma [ISS]
- response to virus [IDA]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DPM1
CDGIE, MPDS, RP5-914P20.2
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- C-terminal protein lipidation [TAS]
- GPI anchor biosynthetic process [IDA]
- cellular protein metabolic process [TAS]
- dolichol metabolic process [IDA]
- dolichol-linked oligosaccharide biosynthetic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein O-linked mannosylation [IDA]
- protein mannosylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID