BAIT
ETAA1
ETAA16
Ewing tumor-associated antigen 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
RPL3
ASC-1, L3, TARBP-B, OK/SW-cl.32
ribosomal protein L3
GO Process (13)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.
The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the exact contribution of the recently discovered ETAA1 pathway to ATR signaling in different contexts remains poorly understood. Here, using an unbiased CRISPR-Cas9-based genome-scale ... [more]
J. Cell Biol. Dec. 02, 2019; 218(12);3943-3953 [Pubmed: 31615875]
Throughput
- High Throughput
Additional Notes
- CRISPR GI screen
- Cell Line: HELA
- Experimental Setup: Negative Selection
- GIST: A-phenotypic negative genetic interaction
- Library: Geckov2
- Significance Threshold: p<0.01
Curated By
- BioGRID