BAIT

EFHD2

SWS1, RP3-467K16.3
EF-hand domain family, member D2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

MTAP

1300019I21Rik, MSAP, RP23-166I8.1
methylthioadenosine phosphorylase
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

A novel calcium-binding protein is associated with tau proteins in tauopathy.

Vega IE, Traverso EE, Ferrer-Acosta Y, Matos E, Colon M, Gonzalez J, Dickson D, Hutton M, Lewis J, Yen SH

Tauopathies are a group of neurological disorders characterized by the presence of intraneuronal hyperphosphorylated and filamentous tau. Mutations in the tau gene have been found in kindred with tauopathy. The expression of the human tau mutant in transgenic mice induced neurodegeneration, indicating that tau plays a central pathological role. However, the molecular mechanism leading to tau-mediated neurodegeneration is poorly understood. ... [more]

J. Neurochem. Jul. 01, 2008; 106(1);96-106 [Pubmed: 18346207]

Throughput

  • Low Throughput

Curated By

  • BioGRID