BAIT
MEF2C
C5DELq14.3, DEL5q14.3
myocyte enhancer factor 2C
GO Process (98)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- MAPK cascade [IDA, IMP]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cardiac ventricle formation [ISS]
- cell morphogenesis involved in neuron differentiation [ISS]
- cellular response to calcium ion [ISS]
- cellular response to drug [ISS]
- cellular response to fluid shear stress [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to parathyroid hormone stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to trichostatin A [ISS]
- chondrocyte differentiation [ISS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in renal tubule morphogenesis [ISS]
- germinal center formation [ISS]
- glomerulus morphogenesis [ISS]
- heart development [IEP, ISS, NAS]
- heart looping [ISS]
- humoral immune response [ISS]
- innate immune response [TAS]
- learning or memory [ISS]
- melanocyte differentiation [ISS]
- muscle cell differentiation [TAS]
- muscle cell fate determination [ISS]
- muscle organ development [TAS]
- myotube differentiation [IEP]
- negative regulation of gene expression [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of ossification [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nephron tubule epithelial cell differentiation [ISS]
- nervous system development [TAS]
- neural crest cell differentiation [ISS]
- neuron development [ISS]
- neuron differentiation [IEP, ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoblast differentiation [ISS]
- outflow tract morphogenesis [ISS]
- platelet formation [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of behavioral fear response [ISS]
- positive regulation of bone mineralization [ISS]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of neuron differentiation [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of protein homodimerization activity [ISS]
- positive regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of skeletal muscle tissue development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- primary heart field specification [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of dendritic spine development [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of germinal center formation [ISS]
- regulation of megakaryocyte differentiation [ISS]
- regulation of neuron apoptotic process [ISS]
- regulation of neurotransmitter secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic activity [ISS]
- regulation of synaptic plasticity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of transcription, DNA-templated [IDA]
- renal tubule morphogenesis [ISS]
- response to ischemia [ISS]
- response to virus [IEP]
- secondary heart field specification [ISS]
- sinoatrial valve morphogenesis [ISS]
- skeletal muscle tissue development [ISS]
- smooth muscle cell differentiation [ISS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [IDA, ISS]
- ventricular cardiac muscle cell differentiation [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
EP300
KAT3B, RSTS2, p300, RP1-85F18.1
E1A binding protein p300
GO Process (29)
GO Function (15)
GO Component (3)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- N-terminal peptidyl-lysine acetylation [IDA]
- Notch signaling pathway [TAS]
- apoptotic process [IMP]
- cellular response to hypoxia [TAS]
- chromatin organization [TAS]
- circadian rhythm [ISS]
- histone H2B acetylation [IDA]
- histone H4 acetylation [IMP]
- innate immune response [TAS]
- internal peptidyl-lysine acetylation [IDA]
- internal protein amino acid acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- positive regulation by host of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [ISS]
- positive regulation of type I interferon production [TAS]
- protein stabilization [ISS]
- regulation of androgen receptor signaling pathway [IDA]
- regulation of cell cycle [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IDA]
- regulation of tubulin deacetylation [IDA]
- response to estrogen [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- acetyltransferase activity [IDA, IMP]
- activating transcription factor binding [IPI]
- androgen receptor binding [IPI]
- beta-catenin binding [IPI]
- chromatin binding [IMP]
- core promoter binding [IDA]
- histone acetyltransferase activity [IDA]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transferase activity, transferring acyl groups [IDA]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- acetyltransferase activity [IDA, IMP]
- activating transcription factor binding [IPI]
- androgen receptor binding [IPI]
- beta-catenin binding [IPI]
- chromatin binding [IMP]
- core promoter binding [IDA]
- histone acetyltransferase activity [IDA]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transferase activity, transferring acyl groups [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.
By searching for molecules that assist MyoD in converting fibroblasts to muscle cells, we have found that p300 and CBP, two related molecules that act as transcriptional adapters, coactivate the myogenic basic-helix-loop-helix (bHLH) proteins. Coactivation by p300 involves novel physical interactions between p300 and the amino-terminal activation domain of MyoD. In particular, disruption of the FYD domain, a group of ... [more]
Mol. Cell. Biol. Feb. 01, 1997; 17(2);1010-26 [Pubmed: 9001254]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MEF2C EP300 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID