BAIT
CUL4A
RP11-391H12.1
cullin 4A
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DDOST
AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, OK/SW-cl.45
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
GO Process (11)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- T cell activation [IDA]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation [IDA]
- protein N-linked glycosylation via asparagine [IC, TAS]
- protein glycosylation [ISS]
- response to cytokine [IDA]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as IL-6 and TNF-? can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-RING E3 Ligases (CRLs) are emerging as master regulators controlling tumorigenesis. Here, we demonstrate that two cullin genes, CUL4A and CUL4B, but not other members, ... [more]
J. Pathol. Aug. 01, 2019; 248(4);464-475 [Pubmed: 30945288]
Throughput
- High Throughput
Curated By
- BioGRID