BAIT
DCAF4
WDR21, WDR21A
DDB1 and CUL4 associated factor 4
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
SPINK5
LEKTI, LETKI, NETS, NS, VAKTI
serine peptidase inhibitor, Kazal type 5
GO Process (9)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- anagen [TAS]
- epidermal cell differentiation [IDA]
- epithelial cell differentiation [TAS]
- extracellular matrix organization [TAS]
- hair cell differentiation [TAS]
- negative regulation of angiogenesis [TAS]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of immune response [TAS]
- regulation of T cell differentiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as IL-6 and TNF-? can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-RING E3 Ligases (CRLs) are emerging as master regulators controlling tumorigenesis. Here, we demonstrate that two cullin genes, CUL4A and CUL4B, but not other members, ... [more]
J. Pathol. Aug. 01, 2019; 248(4);464-475 [Pubmed: 30945288]
Throughput
- High Throughput
Curated By
- BioGRID