BAIT
DCAF4
WDR21, WDR21A
DDB1 and CUL4 associated factor 4
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
WNT16
wingless-type MMTV integration site family, member 16
GO Process (12)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- cell fate commitment [IBA]
- keratinocyte differentiation [IMP]
- keratinocyte proliferation [IMP]
- negative regulation of cell death [IMP]
- neuron differentiation [IBA]
- optic cup formation involved in camera-type eye development [ISS]
- oxidative stress-induced premature senescence [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- replicative senescence [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as IL-6 and TNF-? can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-RING E3 Ligases (CRLs) are emerging as master regulators controlling tumorigenesis. Here, we demonstrate that two cullin genes, CUL4A and CUL4B, but not other members, ... [more]
J. Pathol. Aug. 01, 2019; 248(4);464-475 [Pubmed: 30945288]
Throughput
- High Throughput
Curated By
- BioGRID