BAIT
MAP3K13
LZK, MEKK13, MLK
mitogen-activated protein kinase kinase kinase 13
GO Process (5)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRRC47
RP1-286D6.3
leucine rich repeat containing 47
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The MAP3K13-TRIM25-FBXW7? axis affects c-Myc protein stability and tumor development.
c-Myc (Myc) is a master transcription factor that is often deregulated and highly expressed by at least 50% of cancers. In many cases, Myc protein levels correlate with resistance to therapy and poor prognosis. However, effective direct inhibition of Myc by pharmacologic approaches has remained unachievable. Here, we identify MAP3K13 as a positive regulator of Myc to promote tumor development. ... [more]
Cell Death Differ. Feb. 01, 2020; 27(2);420-433 [Pubmed: 31186535]
Throughput
- Low Throughput
Curated By
- BioGRID