BAIT

LRIG1

LIG-1, LIG1
leucine-rich repeats and immunoglobulin-like domains 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

GLRX3

GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, HUSSY-22
glutaredoxin 3
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors.

Faraz M, Herdenberg C, Holmlund C, Henriksson R, Hedman H

Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. The molecular mechanisms by which LRIG1 mediates its tumor suppressor effects and regulates receptor tyrosine kinases remain incompletely understood. Here, we performed a yeast two-hybrid screen to identify novel LRIG1-interacting proteins and mined data from the BioPlex (biophysical interactions of ... [more]

J. Biol. Chem. Dec. 02, 2017; 293(9);3421-3435 [Pubmed: 29317492]

Throughput

  • High Throughput

Curated By

  • BioGRID