Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination.

Wang CY, Deneen B, Tzeng SF

Oligodendrocytes (OLs) provide the myelin sheath surrounding axons that propagates action potentials in the central nervous system (CNS). The metabolism of myelinated membranes and proteins is strictly regulated in the OLs and is closely associated with OL differentiation and maturation. The ubiquitination-associated proteasome and endosomal system have not yet been well studied during OL differentiation and maturation. Here, we determined ... [more]

Glia Dec. 01, 2018; 67(9);1775-1792 [Pubmed: 31184779]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

EEA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol binding [IDA]GTP-dependent protein binding [IDA]calmodulin binding [NAS]protein binding [IPI]protein homodimerization activity [IDA]zinc ion binding [TAS]

Gene Ontology Cellular Component

PLP1