ABCG1
Gene Ontology Biological Process
- amyloid precursor protein catabolic process [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- detection of hormone stimulus [NAS]
- glycoprotein transport [IDA]
- high-density lipoprotein particle remodeling [ISS]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle remodeling [ISS]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IMP]
- phospholipid homeostasis [IMP]
- positive regulation of cholesterol biosynthetic process [ISS]
- regulation of cholesterol esterification [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to lipid [IDA]
- response to organic substance [IDA]
- reverse cholesterol transport [ISS]
- small molecule metabolic process [TAS]
- toxin transport [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
Gene Ontology Cellular Component
NEDD4
Gene Ontology Biological Process
- cellular response to UV [IMP]
- cytokine-mediated signaling pathway [TAS]
- development involved in symbiotic interaction [IMP]
- glucocorticoid receptor signaling pathway [IDA]
- lysosomal transport [IDA]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- neuron projection development [IEP]
- positive regulation of nucleocytoplasmic transport [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein catabolic process [IDA]
- progesterone receptor signaling pathway [IDA]
- protein K63-linked ubiquitination [ISS]
- protein targeting to lysosome [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, IMP]
- receptor catabolic process [IDA]
- receptor internalization [IDA]
- regulation of dendrite morphogenesis [ISS]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane potential [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- response to calcium ion [TAS]
- transmission of virus [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function- RNA polymerase binding [IPI]
- beta-2 adrenergic receptor binding [IDA]
- phosphoserine binding [ISS]
- phosphothreonine binding [ISS]
- proline-rich region binding [IMP, IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sodium channel inhibitor activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin-protein transferase activity [IDA]
- RNA polymerase binding [IPI]
- beta-2 adrenergic receptor binding [IDA]
- phosphoserine binding [ISS]
- phosphothreonine binding [ISS]
- proline-rich region binding [IMP, IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sodium channel inhibitor activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin-protein transferase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.
Several ATP-Binding Cassette (ABC) transporters, including ABCG1 and the related ABCG4, are essential regulators of cellular lipid homeostasis. ABCG1 is expressed ubiquitously and is functional in the context of atherosclerosis. However, ABCG4 is expressed almost exclusively in brain and has been linked to Alzheimer's disease (AD). These transporters are highly regulated post-translationally by E3 ubiquitin ligases, with the ligase NEDD4-1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ABCG1 NEDD4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID