BAIT
DAB1
AI956902, C630028C02Rik, scm, scr, scrambler, yot, RP23-356E21.1
disabled 1
GO Process (20)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- Golgi localization [IMP]
- adult walking behavior [IMP]
- cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [IMP]
- central nervous system development [TAS]
- cerebellum structural organization [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex radially oriented cell migration [IGI, IMP, ISO]
- dendrite development [IGI, IMP]
- intracellular signal transduction [TAS]
- lateral motor column neuron migration [IMP]
- negative regulation of JAK-STAT cascade [IMP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of axonogenesis [IGI, IMP]
- negative regulation of cell adhesion [IMP]
- nervous system development [NAS]
- neuron migration [IGI, IMP, ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of protein kinase activity [IGI]
- radial glia guided migration of Purkinje cell [IGI, IMP]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NCK2
4833426I10Rik, Grb4, NCKbeta, Nck-2
non-catalytic region of tyrosine kinase adaptor protein 2
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- actin filament organization [IMP]
- cell migration [IMP]
- dendritic spine development [ISO]
- ephrin receptor signaling pathway [IDA]
- immunological synapse formation [ISO]
- lamellipodium assembly [IMP]
- positive regulation of T cell proliferation [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Disabled 1 (Dab1) functions as a critical adapter protein in the Reelin signaling pathway to direct proper positioning of neurons during brain development. Reelin stimulates phosphorylation of Dab1 on tyrosines 198 and 220, and phosphorylated Dab1 is likely to interact with downstream signaling proteins that contain Src homology 2 (SH2) domains. To search for such proteins, we used a Sepharose-conjugated ... [more]
Biochem. Biophys. Res. Commun. May. 21, 2004; 318(1);204-12 [Pubmed: 15110774]
Throughput
- Low Throughput
Curated By
- BioGRID