DAB1
Gene Ontology Biological Process
- Golgi localization [IMP]
- adult walking behavior [IMP]
- cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [IMP]
- central nervous system development [TAS]
- cerebellum structural organization [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex radially oriented cell migration [IGI, IMP, ISO]
- dendrite development [IGI, IMP]
- intracellular signal transduction [TAS]
- lateral motor column neuron migration [IMP]
- negative regulation of JAK-STAT cascade [IMP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of axonogenesis [IGI, IMP]
- negative regulation of cell adhesion [IMP]
- nervous system development [NAS]
- neuron migration [IGI, IMP, ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of protein kinase activity [IGI]
- radial glia guided migration of Purkinje cell [IGI, IMP]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CRKL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Disabled 1 (Dab1) functions as a critical adapter protein in the Reelin signaling pathway to direct proper positioning of neurons during brain development. Reelin stimulates phosphorylation of Dab1 on tyrosines 198 and 220, and phosphorylated Dab1 is likely to interact with downstream signaling proteins that contain Src homology 2 (SH2) domains. To search for such proteins, we used a Sepharose-conjugated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAB1 CRKL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| CRKL DAB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DAB1 CRKL | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| DAB1 CRKL | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID