GRIA2
Gene Ontology Biological Process
- establishment of protein localization [IMP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO, ISS]
- positive regulation of synaptic transmission [IMP]
- protein tetramerization [IDA]
- receptor internalization [IDA]
- regulation of receptor recycling [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- cell surface [IDA]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA, IPI]
- synapse [IDA, ISO]
- synaptic vesicle [ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [IDA]
NSF
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO, TAS]
- Golgi to plasma membrane protein transport [IBA]
- Golgi vesicle docking [IBA]
- intra-Golgi vesicle-mediated transport [IBA]
- membrane fusion [TAS]
- neurotransmitter secretion [TAS]
- positive regulation of receptor recycling [ISO]
- potassium ion transport [ISO]
- protein transport [IMP]
- regulation of exocytosis [IMP]
- vesicle fusion [TAS]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons.
In hippocampal neurons, the exocytotic process of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors is known to depend on activation of N-methyl-d-aspartate channels and its resultant Ca(2+) influx from extracellular spaces. Here we found that brain-derived neurotrophic factor (BDNF) induced a rapid surface translocation of AMPA receptors in an activity-independent manner in developing neocortical neurons. The receptor translocation became evident within hours ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID