PRDX2
Gene Ontology Biological Process
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- cellular response to oxidative stress [ISO]
- homeostasis of number of cells [IMP]
- hydrogen peroxide catabolic process [IMP]
- hydrogen peroxide metabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- oxidation-reduction process [ISS]
- positive regulation of blood coagulation [IMP]
- regulation of apoptotic process [ISO]
- regulation of hydrogen peroxide metabolic process [IMP]
- removal of superoxide radicals [IMP, ISO]
- respiratory burst involved in inflammatory response [IMP]
- response to lipopolysaccharide [IMP]
- response to oxidative stress [ISO, TAS]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DPYSL2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay.
Hydrogen peroxide (H2O2) acts as a signaling molecule in cells by oxidising cysteine residues in regulatory proteins such as phosphatases, kinases and transcription factors. It is unclear exactly how many of these proteins are specifically targeted by H2O2 because they appear too unreactive to be directly oxidised. One proposal is that peroxiredoxins (Prxs) initially react with H2O2 and then oxidise ... [more]
Throughput
- Low Throughput
Additional Notes
- MEF cell extracts
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PRDX2 DPYSL2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2640232 |
Curated By
- BioGRID