BAIT
PELI1
pellino E3 ubiquitin protein ligase 1
GO Process (11)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.
Pellino1 is an E3 ubiquitin ligase that plays a key role in positive regulation of innate immunity signaling, specifically required for the production of interferon when induced by viral double-stranded RNA. We report the identification of the tumor suppressor protein, p53, as a binding partner of Pellino1. Their interaction has a Kd of 42?±?2??M and requires phosphorylation of Thr18 within ... [more]
Biochem. Biophys. Res. Commun. Jun. 04, 2019; 513(3);714-720 [Pubmed: 30987826]
Throughput
- High Throughput
Curated By
- BioGRID