FNTA
Gene Ontology Biological Process
- negative regulation of apoptotic process [IMP]
- negative regulation of nitric-oxide synthase biosynthetic process [IMP]
- neurotransmitter receptor metabolic process [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of deacetylase activity [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IMP]
- positive regulation of tubulin deacetylation [ISO]
- protein farnesylation [ISO, ISS]
- protein geranylgeranylation [ISO, ISS]
- regulation of receptor activity [ISO]
- response to cytokine [IMP]
- response to inorganic substance [IMP]
- response to organic cyclic compound [IMP]
Gene Ontology Molecular Function- CAAX-protein geranylgeranyltransferase activity [IDA]
- Rab geranylgeranyltransferase activity [ISO]
- acetylcholine receptor regulator activity [ISO]
- alpha-tubulin binding [ISO]
- drug binding [IDA]
- isoprenoid binding [IDA]
- microtubule binding [ISO]
- peptide binding [IDA]
- protein binding [IPI]
- protein farnesyltransferase activity [IDA, ISO]
- protein geranylgeranyltransferase activity [ISO, ISS]
- receptor tyrosine kinase binding [ISO]
- zinc ion binding [IDA]
- CAAX-protein geranylgeranyltransferase activity [IDA]
- Rab geranylgeranyltransferase activity [ISO]
- acetylcholine receptor regulator activity [ISO]
- alpha-tubulin binding [ISO]
- drug binding [IDA]
- isoprenoid binding [IDA]
- microtubule binding [ISO]
- peptide binding [IDA]
- protein binding [IPI]
- protein farnesyltransferase activity [IDA, ISO]
- protein geranylgeranyltransferase activity [ISO, ISS]
- receptor tyrosine kinase binding [ISO]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
HRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA, IMP]
- cell surface receptor signaling pathway [TAS]
- cellular senescence [IDA]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- mitotic cell cycle checkpoint [IDA]
- negative regulation of Rho GTPase activity [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of miRNA metabolic process [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of wound healing [IDA]
- signal transduction [NAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid.
S-trans,trans-Farnesylthiosalicylic acid (FTS) is a novel farnesylated rigid carboxylic acid derivative. In cell-free systems, it acts as a potent competitive inhibitor (Ki = 2.6 microM) of the enzyme prenylated protein methyltransferase (PPMTase), which methylates the carboxyl-terminal S-prenylcysteine in a large number of prenylated proteins including Ras. In such systems, FTS inhibits Ras methylation but not Ras farnesylation. Inhibition of the ... [more]
Throughput
- Low Throughput
Additional Notes
- Farnesylation
Curated By
- BioGRID