BAIT
MAP2K5
HsT17454, MAPKK5, MEK5, PRKMK5
mitogen-activated protein kinase kinase 5
GO Process (16)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- activation of MAPK activity [ISS]
- cellular response to growth factor stimulus [ISS]
- cellular response to laminar fluid shear stress [TAS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [ISS]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- negative regulation of heterotypic cell-cell adhesion [ISS]
- negative regulation of interleukin-8 biosynthetic process [ISS]
- negative regulation of response to cytokine stimulus [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein metabolic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
EPHA2
ARCC2, CTPA, CTPP1, CTRCT6, ECK
EPH receptor A2
GO Process (23)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IMP]
- bone remodeling [ISS]
- branching involved in mammary gland duct morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- ephrin receptor signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- keratinocyte differentiation [IMP]
- lens fiber cell morphogenesis [ISS]
- mammary gland epithelial cell proliferation [ISS]
- multicellular organismal development [TAS]
- negative regulation of protein kinase B signaling [IDA]
- osteoblast differentiation [ISS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- protein kinase B signaling [IDA]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of angiogenesis [ISS]
- regulation of blood vessel endothelial cell migration [ISS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of lamellipodium assembly [IMP]
- response to growth factor [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs) with functional and therapeutic significance. Here, we report the generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in ... [more]
Nat Commun Feb. 16, 2017; 8();14356 [Pubmed: 28205554]
Throughput
- High Throughput
Additional Notes
- Time-resolved fluorescence energy transfer (TR-FRET)
Curated By
- BioGRID