BAIT
GRM1
GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13
glutamate receptor, metabotropic 1
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, IMP]
- G-protein coupled receptor signaling pathway [IDA]
- dimeric G-protein coupled receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of synaptic transmission, glutamatergic [IBA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDKN2C
INK4C, p18, p18-INK4C, RP11-278J17.2
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
GO Process (8)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- cell cycle arrest [IDA]
- mitotic cell cycle [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
Gene Ontology Molecular Function
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs) with functional and therapeutic significance. Here, we report the generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in ... [more]
Nat Commun Feb. 16, 2017; 8();14356 [Pubmed: 28205554]
Throughput
- High Throughput
Additional Notes
- Time-resolved fluorescence energy transfer (TR-FRET)
Curated By
- BioGRID