BAIT
IGF1R
CD221, IGFIR, IGFR, JTK13
insulin-like growth factor 1 receptor
GO Process (15)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- immune response [IMP]
- inactivation of MAPKK activity [IDA]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [IMP]
- phosphatidylinositol 3-kinase signaling [IC]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of JNK cascade [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CDK4
CMM3, PSK-J3
cyclin-dependent kinase 4
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- mitotic cell cycle [TAS]
- negative regulation of cell cycle arrest [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IMP]
- protein phosphorylation [IDA]
- regulation of gene expression [IMP]
- response to drug [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs) with functional and therapeutic significance. Here, we report the generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in ... [more]
Nat Commun Feb. 16, 2017; 8();14356 [Pubmed: 28205554]
Throughput
- High Throughput
Additional Notes
- Time-resolved fluorescence energy transfer (TR-FRET)
Curated By
- BioGRID