SLC6A4
Gene Ontology Biological Process
- brain development [IEP]
- brain morphogenesis [ISO]
- cellular response to cGMP [IDA]
- cellular response to organic substance [ISO]
- cellular response to retinoic acid [IEP]
- circadian rhythm [IMP]
- locomotory behavior [NAS]
- memory [IMP]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of organ growth [ISO]
- negative regulation of synaptic transmission, dopaminergic [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of gene expression [ISO]
- protein homooligomerization [IDA]
- protein oligomerization [IDA]
- response to drug [IEP]
- response to estradiol [IEP]
- response to hypoxia [IEP]
- response to nutrient [IEP]
- response to organic substance [IEP]
- response to toxic substance [ISO]
- serotonin transport [IDA, IMP, ISO, TAS]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [ISO]
- sperm ejaculation [IMP]
- thalamus development [ISO]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [IDA]
- cocaine binding [IMP]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [IPI]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IMP]
- serotonin transmembrane transporter activity [IDA, IMP, ISO, ISS, TAS]
- serotonin:sodium symporter activity [ISO, ISS]
- syntaxin-1 binding [IPI]
- Rab GTPase binding [ISO]
- actin filament binding [IDA]
- cocaine binding [IMP]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [IPI]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IMP]
- serotonin transmembrane transporter activity [IDA, IMP, ISO, ISS, TAS]
- serotonin:sodium symporter activity [ISO, ISS]
- syntaxin-1 binding [IPI]
Gene Ontology Cellular Component
VAMP2
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- calcium ion-dependent exocytosis [ISO]
- cellular response to insulin stimulus [ISO]
- eosinophil degranulation [ISO]
- long-term synaptic potentiation [ISO]
- membrane fusion [ISO]
- mucus secretion [ISO]
- natural killer cell degranulation [ISO]
- neurotransmitter secretion [IBA]
- neutrophil degranulation [ISO]
- positive regulation of intracellular protein transport [ISO]
- protein complex assembly [IDA]
- protein transport [IMP]
- regulation of exocytosis [IMP, ISO, TAS]
- regulation of histamine secretion by mast cell [ISO]
- regulation of vesicle-mediated transport [ISO]
- response to glucose [IDA]
- synaptic vesicle exocytosis [ISO]
- vesicle fusion [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [ISO]
- identical protein binding [IPI]
- myosin binding [IPI]
- phospholipid binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [IDA, IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [ISO]
- identical protein binding [IPI]
- myosin binding [IPI]
- phospholipid binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [IDA, IPI]
Gene Ontology Cellular Component
- SNARE complex [IDA, ISO]
- cell [ISO]
- clathrin-coated vesicle [ISO, ISS]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- intracellular organelle [IDA]
- membrane [ISO, ISS]
- neuron projection [IDA]
- neuron projection terminus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [IDA, ISO]
- secretory granule membrane [ISO]
- synapse [ISO]
- synaptic vesicle [IBA, IDA, ISO]
- synaptic vesicle membrane [ISO, NAS]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
- terminal bouton [IDA]
- trans-Golgi network [ISO]
- zymogen granule membrane [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin.
The serotonin transporter (SERT) is a key regulator of serotonergic signalling as it mediates the re-uptake of synaptic serotonin into nerve terminals, thereby terminating or modulating its signal. It is well-known that SERT regulation is a dynamic process orchestrated by a wide array of proteins and mechanisms. However, molecular details on possible coordinated regulation of SERT activity and 5-HT release ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID