RASGRF1
Gene Ontology Biological Process
- activation of Rac GTPase activity [IDA]
- cell proliferation [IMP]
- neuron projection development [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of Ras protein signal transduction [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IGI]
- regulation of Rac protein signal transduction [IDA]
- regulation of Ras protein signal transduction [IDA]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of synaptic plasticity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA]
- growth cone [IDA]
NTRK3
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- activation of Ras GTPase activity [ISO]
- activation of protein kinase B activity [ISO]
- cellular response to retinoic acid [IEP]
- cochlea development [IEP]
- lens fiber cell differentiation [ISO]
- mechanoreceptor differentiation [ISO]
- modulation by virus of host transcription [IEP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell death [IMP]
- negative regulation of protein phosphorylation [ISO]
- neuron fate specification [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IMP, ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of axon extension involved in regeneration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- protein autophosphorylation [IMP]
- response to axon injury [IEP]
- response to corticosterone [IEP]
- response to ethanol [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.
Ras guanine-releasing factor 1 (RasGrf1), a guanine nucleotide exchange factor for members of the Ras and Rho family of GTPases, is highly expressed in the brain. It is regulated by two separate mechanisms, calcium regulation through interaction with its calcium/calmodulin-binding IQ domain and serine and tyrosine phosphorylation. RasGrf1 is activated downstream of G-protein-coupled receptors and the non-receptor tyrosine kinases, Src ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID