FKBP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP3CA
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcineurin-NFAT signaling cascade [IDA, IGI, ISO]
- calcium ion transport [IMP]
- calcium-mediated signaling [IGI]
- cardiac muscle hypertrophy in response to stress [IGI]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [ISO]
- dephosphorylation [IDA]
- multicellular organismal response to stress [IDA]
- negative regulation of chromatin binding [IMP]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of insulin secretion [ISO]
- positive regulation of NFAT protein import into nucleus [IDA, IMP, ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- protein dephosphorylation [IMP, ISO]
- protein import into nucleus [IDA]
- regulation of excitatory postsynaptic membrane potential [IGI]
- regulation of synaptic transmission [IMP]
- response to calcium ion [ISO]
- skeletal muscle fiber development [IMP]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin.
FKBP51 is a member of the immunophilin family having intrinsic peptidyl-prolyl cis-trans-isomerase (PPIase) activity. Its enzymatic activity is inhibited by binding either immunosuppressive agent FK506 or rapamycin. Similar to FKBP12, but at higher concentrations of FK506, FKBP51 has been shown to inhibit the serine/threonine phosphatase activity of calcineurin in the presence of calcium and calmodulin. Here we show that a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID