BAIT
PTPRO
GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O
protein tyrosine phosphatase, receptor type, O
GO Process (15)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- axon guidance [ISS]
- cell morphogenesis [ISS]
- glomerular visceral epithelial cell differentiation [ISS]
- glomerulus development [IMP]
- lamellipodium assembly [ISS]
- monocyte chemotaxis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of glomerular filtration [ISS]
- negative regulation of neuron projection development [ISS]
- negative regulation of retinal ganglion cell axon guidance [ISS]
- peptidyl-tyrosine dephosphorylation [IMP]
- protein dephosphorylation [ISS, TAS]
- regulation of glomerular filtration [ISS]
- slit diaphragm assembly [ISS, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ASPH
AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin
aspartate beta-hydroxylase
GO Process (17)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IDA]
- activation of store-operated calcium channel activity [IDA]
- calcium ion transmembrane transport [IDA]
- cellular response to calcium ion [IDA]
- detection of calcium ion [TAS]
- muscle contraction [TAS]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of intracellular protein transport [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- response to ATP [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [TAS]
- cortical endoplasmic reticulum [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [NAS]
- integral component of endoplasmic reticulum membrane [IDA]
- junctional sarcoplasmic reticulum membrane [TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID