BAIT
PTPN11
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
protein tyrosine phosphatase, non-receptor type 11
GO Process (27)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DCAF7
AN11, HAN11, SWAN-1, WDR68
DDB1 and CUL4 associated factor 7
GO Process (1)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID