PTPN2
Gene Ontology Biological Process
- B cell differentiation [ISS]
- T cell differentiation [ISS]
- cytokine-mediated signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemotaxis [ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of inflammatory response [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of interferon-gamma-mediated signaling pathway [ISS]
- negative regulation of interleukin-2-mediated signaling pathway [IMP]
- negative regulation of interleukin-4-mediated signaling pathway [IMP]
- negative regulation of interleukin-6-mediated signaling pathway [IMP]
- negative regulation of lipid storage [ISS]
- negative regulation of macrophage colony-stimulating factor signaling pathway [ISS]
- negative regulation of macrophage differentiation [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of positive thymic T cell selection [ISS]
- negative regulation of prolactin signaling pathway [ISS]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISS]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of tyrosine phosphorylation of Stat1 protein [IDA, IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- positive regulation of gluconeogenesis [ISS]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KPNA1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of virus [TAS]
- positive regulation of protein import into nucleus [ISS]
- regulation of DNA recombination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN2 KPNA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2296167 | |
| PTPN2 KPNA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID