BAIT
PTPRO
GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O
protein tyrosine phosphatase, receptor type, O
GO Process (15)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- axon guidance [ISS]
- cell morphogenesis [ISS]
- glomerular visceral epithelial cell differentiation [ISS]
- glomerulus development [IMP]
- lamellipodium assembly [ISS]
- monocyte chemotaxis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of glomerular filtration [ISS]
- negative regulation of neuron projection development [ISS]
- negative regulation of retinal ganglion cell axon guidance [ISS]
- peptidyl-tyrosine dephosphorylation [IMP]
- protein dephosphorylation [ISS, TAS]
- regulation of glomerular filtration [ISS]
- slit diaphragm assembly [ISS, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LNPEP
CAP, IRAP, P-LAP, PLAP
leucyl/cystinyl aminopeptidase
GO Process (7)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cell-cell signaling [TAS]
- female pregnancy [TAS]
- membrane organization [TAS]
- protein polyubiquitination [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID