BAIT
CDC25B
RP5-1009E24.3
cell division cycle 25B
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
- spindle pole [IDA]
Homo sapiens
PREY
MSH2
COCA1, FCC1, HNPCC, HNPCC1, LCFS2
mutS homolog 2
GO Process (22)
GO Function (25)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- B cell differentiation [ISS]
- B cell mediated immunity [ISS]
- DNA repair [IDA]
- double-strand break repair [IBA]
- intra-S DNA damage checkpoint [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- male gonad development [ISS]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI]
- negative regulation of DNA recombination [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of reciprocal meiotic recombination [IBA]
- positive regulation of helicase activity [IDA]
- postreplication repair [IDA]
- response to UV-B [IBA, ISS]
- response to X-ray [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID