PXL1
Gene Ontology Biological Process
- mitotic actomyosin contractile ring assembly [IGI, IMP]
- negative regulation of Rho GTPase activity [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- regulation of Rho protein signal transduction [IGI]
- regulation of mitotic actomyosin contractile ring assembly [IGI]
- regulation of mitotic actomyosin contractile ring contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BGS1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
Schizosaccharomyces pombe Rho GTPases regulate actin cytoskeleton organization and cell integrity. We studied the fission yeast gene SPBC4F6.12 based on its ability to suppress the thermosensitivity of cdc42-1625 mutant strain. This gene, named pxl1(+), encodes a protein with three LIM domains that is similar to paxillin. Pxl1 does not interact with Cdc42 but it interacts with Rho1, and it negatively ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BGS1 PXL1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2334380 |
Curated By
- BioGRID