BAIT
PTPRM
PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
protein tyrosine phosphatase, receptor type, M
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- neuron projection development [IDA, IMP]
- peptidyl-tyrosine dephosphorylation [IDA]
- protein dephosphorylation [IDA]
- response to drug [IDA]
- retina layer formation [IMP]
- retinal ganglion cell axon guidance [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE3C
HECTH2, tcag7.998
ubiquitin protein ligase E3C
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID