BAIT
DUSP4
HVH2, MKP-2, MKP2, TYP
dual specificity phosphatase 4
GO Process (18)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- endoderm formation [IBA]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- protein dephosphorylation [IBA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [TAS]
Homo sapiens
PREY
USP47
TRFP
ubiquitin specific peptidase 47
GO Process (12)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- base-excision repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to UV [ISS]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell growth [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of proteasomal protein catabolic process [IBA]
- response to drug [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Tyrosine phosphatases play a critical role in many cellular processes and pathogenesis, yet comprehensive analysis of their functional interacting proteins in the cell is limited. By utilizing a proteomic approach, here we present an interaction network of 81 human tyrosine phosphatases built on 1884 high-confidence interactions of which 85% are unreported. Our analysis has linked several phosphatases with new cellular ... [more]
J. Proteome Res. Dec. 04, 2016; 16(8);2789-2801 [Pubmed: 28675297]
Throughput
- High Throughput
Curated By
- BioGRID