SLC18A2
Gene Ontology Biological Process
- aging [IDA]
- cellular response to ammonium ion [IEP]
- cellular response to drug [IDA]
- death [ISO]
- endocytic recycling [IEP]
- glucose homeostasis [IDA]
- insulin secretion [IDA]
- locomotory behavior [ISO]
- monoamine transport [IDA]
- negative regulation of neurotransmitter transport [IMP]
- neurotransmitter transport [IDA]
- post-embryonic development [ISO]
- response to amphetamine [IEP, ISO]
- response to cocaine [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to herbicide [IEP]
- response to metal ion [IEP]
- response to starvation [IEP]
- response to toxic substance [ISO]
- response to zinc ion [IEP]
- serotonin transport [IDA]
- synaptic vesicle amine transport [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DDC
Gene Ontology Biological Process
- catecholamine biosynthetic process [TAS]
- cellular response to alkaloid [IEP]
- cellular response to drug [IEP]
- cellular response to growth factor stimulus [IEP]
- circadian rhythm [IEP]
- dopamine biosynthetic process [IDA]
- dopamine metabolic process [TAS]
- isoquinoline alkaloid metabolic process [IEP]
- multicellular organismal aging [IEP]
- phytoalexin metabolic process [IEP]
- response to pyrethroid [IEP]
- response to toxic substance [ISO]
- serotonin biosynthetic process [IDA]
- synaptic vesicle amine transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles.
Synaptic transmission depends on neurotransmitter pools stored within vesicles that undergo regulated exocytosis. In the brain, the vesicular monoamine transporter-2 (VMAT(2)) is responsible for the loading of dopamine (DA) and other monoamines into synaptic vesicles. Prior to storage within vesicles, DA synthesis occurs at the synaptic terminal in a two-step enzymatic process. First, the rate-limiting enzyme tyrosine hydroxylase (TH) converts ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID