CRADD
Gene Ontology Biological Process
Gene Ontology Molecular Function
RIPK1
Gene Ontology Biological Process
- T cell apoptotic process [IMP]
- amyloid fibril formation [ISO]
- apoptotic process [ISO]
- cellular protein catabolic process [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to tumor necrosis factor [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- necroptotic process [IGI, ISO]
- necroptotic signaling pathway [IMP, ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- peptidyl-serine autophosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of JNK cascade [IMP, ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of necroptotic process [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of programmed cell death [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transferase activity [IGI]
- positive regulation of tumor necrosis factor production [ISO]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- regulation of ATP:ADP antiporter activity [ISO]
- regulation of reactive oxygen species metabolic process [IMP]
- response to tumor necrosis factor [ISO]
- ripoptosome assembly [ISO]
- ripoptosome assembly involved in necroptotic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans.
Recent studies have implicated Fas in the pathogenesis of inflammatory, ischemic, and traumatic brain injury (TBI); however, a direct link between Fas activation and caspase-mediated cell death has not been established in injured brain. We detected Fas-Fas ligand binding and assembly of death-inducing signaling complexes (DISCs) [Fas, Fas-associated protein with death domain, and procaspase-8 or procaspase-10; receptor interacting protein (RIP)-RIP-associated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID