PREY

RIPK1

D330015H01Rik, RIP, Rinp, Rip1
receptor (TNFRSF)-interacting serine-threonine kinase 1
GO Process (37)
GO Function (8)
GO Component (7)

Gene Ontology Biological Process

Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans.

Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA

Recent studies have implicated Fas in the pathogenesis of inflammatory, ischemic, and traumatic brain injury (TBI); however, a direct link between Fas activation and caspase-mediated cell death has not been established in injured brain. We detected Fas-Fas ligand binding and assembly of death-inducing signaling complexes (DISCs) [Fas, Fas-associated protein with death domain, and procaspase-8 or procaspase-10; receptor interacting protein (RIP)-RIP-associated ... [more]

J. Neurosci. May. 01, 2002; 22(9);3504-11 [Pubmed: 11978827]

Throughput

  • Low Throughput

Curated By

  • BioGRID