SCN1B
Gene Ontology Biological Process
- axon guidance [ISO]
- cardiac conduction [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- corticospinal neuron axon guidance [ISO]
- locomotion [ISO]
- membrane depolarization [ISO]
- membrane depolarization during Purkinje myocyte cell action potential [ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential propagation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of sodium ion transmembrane transporter activity [ISO]
- regulation of sodium ion transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to pyrethroid [IDA]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function- protein binding [IPI]
- sodium channel inhibitor activity [ISO]
- sodium channel regulator activity [IDA, ISO]
- voltage-gated sodium channel activity [ISO]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [ISO]
- sodium channel regulator activity [IDA, ISO]
- voltage-gated sodium channel activity [ISO]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
Gene Ontology Cellular Component
NFASC
Gene Ontology Biological Process
- axon guidance [ISO]
- clustering of voltage-gated sodium channels [ISO]
- heterotypic cell-cell adhesion [ISO]
- myelination [IEP]
- paranodal junction assembly [ISO]
- peripheral nervous system development [IEP]
- protein localization to juxtaparanode region of axon [ISO]
- protein localization to paranode region of axon [ISO]
- protein targeting to plasma membrane [IDA]
- synapse organization [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain.
Sequence homology predicts that the extracellular domain of the sodium channel beta1 subunit forms an immunoglobulin (Ig) fold and functions as a cell adhesion molecule. We show here that beta1 subunits associate with neurofascin, a neuronal cell adhesion molecule that plays a key role in the assembly of nodes of Ranvier. The first Ig-like domain and second fibronectin type III-like ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID