BAIT
MDM2
ACTFS, HDMX, hdm2
MDM2 proto-oncogene, E3 ubiquitin protein ligase
GO Process (25)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TP53
Trp53, p53
tumor protein p53
GO Process (119)
GO Function (32)
GO Component (17)
Gene Ontology Biological Process
- B cell lineage commitment [ISO]
- DNA damage response, signal transduction by p53 class mediator [ISO]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISO]
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA, ISO]
- DNA strand renaturation [ISO, ISS]
- ER overload response [ISO]
- Ras protein signal transduction [ISO]
- T cell differentiation in thymus [ISO]
- T cell lineage commitment [ISO]
- T cell proliferation involved in immune response [ISO]
- aging [IEP]
- apoptotic process [ISO]
- cell aging [ISO, ISS]
- cell cycle arrest [ISO]
- cellular protein localization [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [IBA, ISO]
- cellular response to drug [ISO]
- cellular response to glucose starvation [ISO]
- cellular response to heat [IEP]
- cellular response to hypoxia [ISO]
- cellular response to ionizing radiation [ISO]
- cellular response to organonitrogen compound [IEP]
- central nervous system development [ISO]
- cerebellum development [ISO]
- chromatin assembly [ISO]
- chromosome organization [ISO]
- determination of adult lifespan [ISO]
- double-strand break repair [ISO]
- embryo development ending in birth or egg hatching [ISO]
- embryonic organ development [ISO]
- gastrulation [ISO]
- in utero embryonic development [ISO]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, ISO]
- mitochondrial DNA repair [ISO]
- mitotic G1 DNA damage checkpoint [IBA, ISO]
- mitotic cell cycle arrest [ISO]
- multicellular organism growth [ISO]
- multicellular organismal development [ISO, ISS]
- necroptotic process [ISO]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of DNA replication [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of cell proliferation [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of macromitophagy [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of neuroblast proliferation [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of smooth muscle cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- neuron apoptotic process [ISO]
- nucleotide-excision repair [ISO, ISS]
- oligodendrocyte apoptotic process [ISO, ISS]
- oxidative stress-induced premature senescence [ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cardiac muscle cell apoptotic process [ISO]
- positive regulation of cell aging [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of histone deacetylation [IBA, ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of leukocyte migration [IMP]
- positive regulation of mitochondrial membrane permeability [ISO]
- positive regulation of neuron apoptotic process [IBA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein oligomerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO, ISS]
- positive regulation of thymocyte apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein complex assembly [ISO]
- protein import into nucleus, translocation [ISO]
- protein localization [ISO]
- rRNA transcription [ISO]
- regulation of apoptotic process [ISO]
- regulation of catalytic activity [ISO]
- regulation of cell cycle [ISO]
- regulation of cell proliferation [ISO]
- regulation of fibroblast apoptotic process [ISO]
- regulation of intracellular pH [IMP]
- regulation of intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of thymocyte apoptotic process [ISO]
- regulation of tissue remodeling [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- regulation of transcription, DNA-templated [ISO]
- release of cytochrome c from mitochondria [ISO]
- replicative senescence [ISO]
- response to UV [IEP, ISO]
- response to UV-B [IEP]
- response to X-ray [IEP, ISO]
- response to amino acid [IEP]
- response to antibiotic [ISO]
- response to caffeine [IEP]
- response to cytokine [IEP]
- response to drug [IEP, ISO]
- response to gamma radiation [IBA, ISO]
- response to hyperoxia [IEP]
- response to inorganic substance [IEP]
- response to ischemia [ISO]
- response to metal ion [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IEP, ISO]
- response to retinoic acid [IEP]
- response to salt stress [ISO]
- response to vitamin B3 [IEP]
- somitogenesis [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- wound healing [IEP]
Gene Ontology Molecular Function- ATP binding [ISO, ISS]
- DNA binding [ISO, ISS]
- MDM2/MDM4 family protein binding [IPI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chaperone binding [ISO]
- chromatin binding [IBA, ISO]
- copper ion binding [ISO, ISS]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase regulator activity [ISO]
- identical protein binding [ISO]
- p53 binding [IBA]
- protease binding [ISO]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- receptor tyrosine kinase binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription cofactor binding [IPI]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ATP binding [ISO, ISS]
- DNA binding [ISO, ISS]
- MDM2/MDM4 family protein binding [IPI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chaperone binding [ISO]
- chromatin binding [IBA, ISO]
- copper ion binding [ISO, ISS]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase regulator activity [ISO]
- identical protein binding [ISO]
- p53 binding [IBA]
- protease binding [ISO]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- receptor tyrosine kinase binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IBA, ISO]
- transcription cofactor binding [IPI]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Gene Ontology Cellular Component
- PML body [ISO]
- chromatin [IDA]
- cytoplasm [IDA, ISO, ISS]
- cytosol [IDA, ISO]
- intracellular [ISO]
- mitochondrial matrix [ISO]
- mitochondrion [IDA, ISO, ISS]
- nuclear body [ISO]
- nuclear chromatin [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO, ISS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- protein complex [ISO]
- replication fork [IBA, ISO]
- transcription factor TFIID complex [ISO]
- transcription factor complex [IDA]
Rattus norvegicus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
Restoration of p53 function through the disruption of the MDM2-p53 protein complex is a promising strategy for the treatment of various types of cancer. Here, we present kinetic, thermodynamic, and structural rationale for the remarkable potency of a new class of MDM2 inhibitors, the piperidinones. While these compounds bind to the same site as previously reported for small molecule inhibitors, ... [more]
J. Am. Chem. Soc. Oct. 17, 2012; 134(41);17059-67 [Pubmed: 22991965]
Throughput
- Low Throughput
Curated By
- BioGRID