BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SERPINB3
HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A
serpin peptidase inhibitor, clade B (ovalbumin), member 3
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage.
Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA damage. The RNA-binding protein HuR activates p53 mRNA translation in response to UVC-induced DNA damage in breast carcinoma cells. ... [more]
iScience May. 31, 2019; 15();342-359 [Pubmed: 31103853]
Throughput
- High Throughput
Curated By
- BioGRID