TLR4
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T-helper 1 type immune response [NAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-negative bacterium [IC]
- defense response to bacterium [TAS]
- detection of fungus [NAS]
- detection of lipopolysaccharide [IDA]
- immune response [TAS]
- innate immune response [TAS]
- intestinal epithelial structure maintenance [ISS]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI]
- macrophage activation [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-23 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of osteoclast differentiation [NAS]
- negative regulation of tumor necrosis factor production [ISS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha production [ISS]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 production [ISS]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of platelet activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of tumor necrosis factor production [ISS]
- response to lipopolysaccharide [IC, IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RNF216
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation.
Paeoniflorin, a polyphenolic compound derived from Radix Paeoniae Alba (Paeonia lactiflora), has exhibited anticancer activity in various human cancers, including glioblastoma. However, the mechanisms underlying the effects of this compound have not been fully elucidated. Toll-like receptor 4 (TLR4) plays an important role in the regulation of cancer cell proliferation and progression, and high TLR4 expression in glioblastoma specimens is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF216 TLR4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID