BAIT
COMP
TSP5
cartilage oligomeric matrix protein
GO Process (4)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANXA1
Anx1, p35
annexin A1
GO Process (39)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- DNA duplex unwinding [IMP]
- DNA rewinding [IMP]
- DNA strand renaturation [IMP]
- alpha-beta T cell differentiation [ISO]
- arachidonic acid secretion [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to glucocorticoid stimulus [IDA, ISO]
- cellular response to hydrogen peroxide [IMP]
- endocrine pancreas development [IEP]
- estrous cycle phase [IEP]
- gliogenesis [IEP]
- hepatocyte differentiation [IEP]
- insulin secretion [IDA]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [IDA]
- negative regulation of protein secretion [IMP]
- neutrophil clearance [ISO]
- neutrophil homeostasis [ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of neutrophil apoptotic process [ISO]
- positive regulation of prostaglandin biosynthetic process [IMP]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [IMP]
- prostate gland development [IEP]
- regulation of cell proliferation [ISO]
- response to X-ray [IEP]
- response to corticosteroid [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucocorticoid [IEP]
- response to hormone [IEP]
- response to interleukin-1 [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
- cell surface [ISO]
- cornified envelope [ISO]
- cytoplasm [IDA, ISO]
- endosome [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- mast cell granule [IDA]
- mitochondrial membrane [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- sarcolemma [ISO]
- vesicle [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
Vascular smooth muscle cells (VSMCs) are highly phenotypically plastic, and loss of the contractile phenotype in VSMCs has been recognized at the early onset of the pathology of a variety of vascular diseases. However, the endogenous regulatory mechanism to maintain contractile phenotype in VSMCs remains elusive. Moreover, little has been known about the role of the mitochondrial bioenergetics in terms ... [more]
Cell Death Dis Dec. 04, 2017; 9(6);676 [Pubmed: 29867124]
Throughput
- High Throughput
Curated By
- BioGRID