BAIT
OTUD4
DUBA6, HIN1, HSHIN1
OTU deubiquitinase 4
GO Process (1)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CPEB3
4831444O18Rik, CPE-BP3, mKIAA0940
cytoplasmic polyadenylation element binding protein 3
GO Process (14)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA destabilization [ISO]
- cellular response to amino acid stimulus [IDA, ISO]
- long-term memory [IMP]
- negative regulation of cytoplasmic translational elongation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of translation [IDA, IMP, ISO]
- positive regulation of dendritic spine development [IDA]
- positive regulation of mRNA polyadenylation [IDA]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISO]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISO]
- positive regulation of translation [IDA]
- regulation of dendritic spine development [IMP]
- regulation of synaptic plasticity [IMP]
- translation [IDA, ISO]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.
Mechanisms that regulate the formation of membrane-less cellular organelles, such as neuronal RNA granules and stress granules, have gained increasing attention over the past years. These granules consist of RNA and a plethora of RNA-binding proteins. Mutations in RNA-binding proteins have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By performing pulldown experiments ... [more]
J. Cell. Sci. Jun. 17, 2019; 132(12); [Pubmed: 31138677]
Throughput
- High Throughput
Curated By
- BioGRID