OTUD4
Gene Ontology Biological Process
Gene Ontology Molecular Function
PURB
Gene Ontology Biological Process
- apoptotic process [NAS]
- cell differentiation [NAS]
- cell proliferation [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of translation [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- mRNA binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [ISO]
- RNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- mRNA binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.
Mechanisms that regulate the formation of membrane-less cellular organelles, such as neuronal RNA granules and stress granules, have gained increasing attention over the past years. These granules consist of RNA and a plethora of RNA-binding proteins. Mutations in RNA-binding proteins have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By performing pulldown experiments ... [more]
Throughput
- High Throughput
Curated By
- BioGRID