BAIT

FAF1

HFAF1s, UBXD12, UBXN3A, hFAF1, CGI-03

Fas (TNFRSF6) associated factor 1

Glioblastoma Project

GO Process (7)

GO Function (7)

GO Component (5)

Gene Ontology Biological Process

cell death [IMP]

cytoplasmic sequestering of NF-kappaB [IMP]

positive regulation of apoptotic process [NAS]

positive regulation of protein complex assembly [IMP]

proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]

regulation of protein catabolic process [IMP]

regulation of protein kinase activity [NAS]

Gene Ontology Molecular Function

NF-kappaB binding [IPI]
heat shock protein binding [IDA]
protein binding [IPI]
protein kinase binding [IDA]
protein kinase regulator activity [NAS]
ubiquitin binding [IDA]
ubiquitin protein ligase binding [IDA]

Gene Ontology Cellular Component

CD95 death-inducing signaling complex [NAS]

Cdc48p-Npl4p-Ufd1p AAA ATPase complex [IDA]

perinuclear region of cytoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

PREY

UBE2I

C358B7.1, P18, UBC9, LA16c-358B7.1

ubiquitin-conjugating enzyme E2I

GO Process (8)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular protein modification process [TAS]

negative regulation of transcription from RNA polymerase II promoter [IMP]

negative regulation of transcription, DNA-templated [IDA]

post-translational protein modification [TAS]

protein sumoylation [IDA, TAS]

protein ubiquitination [IBA]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

RING-like zinc finger domain binding [IPI]
SUMO transferase activity [IDA]
enzyme binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
transcription factor binding [IPI]
ubiquitin protein ligase activity [IBA]
ubiquitin protein ligase binding [IBA]
ubiquitin-protein transferase activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleoplasm [TAS]

synaptonemal complex [TAS]

transferase complex [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation.

Wang CH, Hung PW, Chiang CW, Lombes M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY

Fas-associated factor 1 (FAF1) was originally isolated as a Fas-associated factor and was subsequently found to interact with numerous other proteins that are involved in various cellular events including Fas-mediated apoptosis, nuclear factor (NF)-?B, Wnt/?-catenin, and transforming growth factor (TGF)-? signaling pathways, mineralocorticoid receptor (MR)-mediated transactivation, and ubiquitin-dependent processes. Herein, we defined two small ubiquitin-like modifier (SUMO)-interacting motifs (SIMs) within ... [more]

Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(8);1282-1297 [Pubmed: 30935967]

Throughput

Low Throughput

Curated By

BioGRID