BAIT
PPP1CA
Ppp1c, dism2
protein phosphatase 1, catalytic subunit, alpha isoform
GO Process (14)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
Mus musculus
PREY
LDB1
CLIM2, NLI
LIM domain binding 1
GO Process (21)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- Wnt signaling pathway [IMP]
- anterior/posterior axis specification [IMP]
- cellular component assembly [IGI]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellum development [IMP]
- epithelial structure maintenance [IGI]
- gastrulation with mouth forming second [IMP]
- hair follicle development [IGI]
- head development [IGI]
- histone H3-K4 acetylation [IMP]
- negative regulation of erythrocyte differentiation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cell adhesion [IGI]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- primitive erythrocyte differentiation [TAS]
- regulation of DNA-templated transcription, elongation [IMP]
- regulation of nucleic acid-templated transcription [IPI]
- somatic stem cell maintenance [IGI]
- transcription from RNA polymerase II promoter [IDA]
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Heart failure (HF) is a complex disease with a rising prevalence despite advances in treatment. Protein phosphatase 1 (PP1) has long been implicated in HF pathogenesis, but its exact role is both unclear and controversial. Most previous studies measured only the PP1 catalytic subunit (PP1c) without investigating its diverse set of interactors, which confer localization and substrate specificity to the ... [more]
Circulation Dec. 09, 2017; 138(15);1569-1581 [Pubmed: 29669786]
Throughput
- High Throughput
Curated By
- BioGRID