BAIT
CACYBP
GIG5, S100A6BP, SIP, PNAS-107
calcyclin binding protein
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BIRC6
APOLLON, BRUCE
baculoviral IAP repeat containing 6
GO Process (7)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
BRUCE/Apollon is a membrane-associated inhibitor of apoptosis protein that is essential for viability and has ubiquitin-conjugating activity. On initiation of apoptosis, the ubiquitin ligase Nrdp1/RNF41 promotes proteasomal degradation of BRUCE. Here we demonstrate that BRUCE together with the proteasome activator PA28? causes proteasomal degradation of LC3-I and thus inhibits autophagy. LC3-I on the phagophore membrane is conjugated to phosphatidylethanolamine to ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 02, 2018; 116(27);13404-13413 [Pubmed: 31213539]
Throughput
- Low Throughput
Curated By
- BioGRID