RAB11A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- astral microtubule organization [ISO]
- cytokinesis [ISO]
- establishment of protein localization to membrane [ISO]
- establishment of protein localization to organelle [ISO]
- establishment of vesicle localization [ISO]
- exocytosis [IBA]
- exosomal secretion [ISO]
- intracellular protein transport [IBA]
- melanosome transport [IMP]
- mitotic metaphase plate congression [ISO]
- multivesicular body assembly [ISO]
- neuron projection development [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of axon extension [IMP]
- positive regulation of epithelial cell migration [ISO]
- protein localization to plasma membrane [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of multivesicular body size [ISO]
- regulation of protein transport [ISO]
- regulation of vesicle-mediated transport [ISO]
- spindle assembly involved in mitosis [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA]
- cell [IMP]
- cleavage furrow [ISO]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- kinetochore microtubule [ISO]
- membrane [IDA]
- mitochondrion [IDA]
- multivesicular body [ISO]
- perinuclear region of cytoplasm [IDA]
- phagocytic vesicle [ISO]
- protein complex [ISO]
- recycling endosome [IDA, ISO]
- spindle pole [ISO]
- trans-Golgi network [ISO]
- transport vesicle [ISO]
- vesicle [ISO]
BIRC6
Gene Ontology Biological Process
- labyrinthine layer development [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of cell proliferation [IMP]
- protein ubiquitination [IC, ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [ISO]
- regulation of signal transduction [IBA]
- spongiotrophoblast layer development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
BRUCE/Apollon is a membrane-associated inhibitor of apoptosis protein that is essential for viability and has ubiquitin-conjugating activity. On initiation of apoptosis, the ubiquitin ligase Nrdp1/RNF41 promotes proteasomal degradation of BRUCE. Here we demonstrate that BRUCE together with the proteasome activator PA28? causes proteasomal degradation of LC3-I and thus inhibits autophagy. LC3-I on the phagophore membrane is conjugated to phosphatidylethanolamine to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID