GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
GRIN2A
Gene Ontology Biological Process
- action potential [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium ion [IEP]
- cellular response to manganese ion [IEP]
- cellular response to zinc ion [IMP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- directional locomotion [ISO]
- dopamine metabolic process [ISO]
- hippocampus development [IEP]
- ion transmembrane transport [IMP, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- memory [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neurogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- protein localization [ISO]
- protein tetramerization [IDA]
- regulation of excitatory postsynaptic membrane potential [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to amine [IEP]
- response to ammonium ion [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to drug [IEP, ISO]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to light stimulus [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to wounding [ISO]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- serotonin metabolic process [ISO]
- sleep [ISO]
- spinal cord development [IEP]
- startle response [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- cell surface [ISO]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [ISO, TAS]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors.
The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2 subunits. Using the novel glycine site antagonist and photoaffinity label CGP 61594, distinct contributions of the NR2 subunit variants to the glycine antagonist binding domains of NMDA receptor subtypes are ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIN2A GRIN1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN1 GRIN2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN1 GRIN2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN1 GRIN2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID