TRPC5
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP1A1
Gene Ontology Biological Process
- ATP catabolic process [ISO, TAS]
- cardiac muscle contraction [TAS]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [ISO]
- energy coupled proton transmembrane transport, against electrochemical gradient [TAS]
- membrane hyperpolarization [IMP]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [ISO]
- negative regulation of heart contraction [ISO]
- positive regulation of heart contraction [ISO]
- positive regulation of striated muscle contraction [ISO]
- potassium ion import [IDA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [IDA]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of sodium ion transport [IDA]
- regulation of the force of heart contraction [ISO]
- relaxation of cardiac muscle [TAS]
- response to drug [ISO]
- response to glycoside [ISO]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IDA, ISO]
- sodium ion transport [IDA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- T-tubule [IDA, ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISS]
- intercalated disc [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- myelin sheath [ISO]
- neuronal postsynaptic density [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [IDA, ISO]
- vesicle [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase.
Mammalian transient receptor potential canonical (TRPC) genes encode a family of nonselective cation channels that are activated following stimulation of G-protein-coupled membrane receptors linked to phospholipase C. In Drosophila photoreceptor cells, TRP channels are found in large, multimolecular signaling complexes in association with the PDZ-containing scaffolding protein, INAD. A similar mammalian TRPC "signalplex" has been proposed, but has yet to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRPC5 ATP1A1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ATP1A1 TRPC5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID