BAIT
YWHAZ
14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COL3A1
AW550625, Col3a-1, MMS10-W, Ms10w, mKIAA4231
collagen, type III, alpha 1
GO Process (19)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- aorta smooth muscle tissue morphogenesis [IMP]
- blood vessel development [IMP]
- cell-matrix adhesion [ISO]
- cellular response to amino acid stimulus [IDA]
- cerebral cortex development [IMP]
- collagen fibril organization [IMP, ISO]
- digestive tract development [IMP]
- extracellular fibril organization [ISO]
- heart development [ISO]
- integrin-mediated signaling pathway [ISO]
- negative regulation of immune response [ISO]
- negative regulation of neuron migration [IMP]
- peptide cross-linking [ISO]
- positive regulation of Rho protein signal transduction [IDA]
- response to cytokine [ISO]
- response to radiation [ISO]
- skin development [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Elucidation of the 14-3-3? interactome reveals critical roles of RNA-splicing factors during adipogenesis.
Adipogenesis involves a complex signaling network requiring strict temporal and spatial organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate such organization, and we have previously identified 14-3-3? as an essential scaffold in adipocyte differentiation. The interactome of 14-3-3? is large and diverse, and it is possible that novel adipogenic factors may be present within it, but this ... [more]
J. Biol. Chem. Dec. 04, 2017; 293(18);6736-6750 [Pubmed: 29530978]
Throughput
- High Throughput
Curated By
- BioGRID