BAIT
YWHAZ
14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
YBX1
1700102N10Rik, C79409, EF1A, MSY1, Nsep1, YB-1, dbpB, mYB-1a, RP24-363D14.2
Y box protein 1
GO Process (10)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- CRD-mediated mRNA stabilization [ISO]
- in utero embryonic development [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of striated muscle cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- CRD-mediated mRNA stability complex [ISO]
- U12-type spliceosomal complex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic stress granule [ISO]
- dendrite [ISO]
- extracellular vesicular exosome [ISO]
- histone pre-mRNA 3'end processing complex [IDA]
- intracellular membrane-bounded organelle [ISO]
- nuclear membrane [ISO]
- nucleus [IGI, ISO]
- perinuclear region of cytoplasm [ISO]
- ribonucleoprotein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Elucidation of the 14-3-3? interactome reveals critical roles of RNA-splicing factors during adipogenesis.
Adipogenesis involves a complex signaling network requiring strict temporal and spatial organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate such organization, and we have previously identified 14-3-3? as an essential scaffold in adipocyte differentiation. The interactome of 14-3-3? is large and diverse, and it is possible that novel adipogenic factors may be present within it, but this ... [more]
J. Biol. Chem. Dec. 04, 2017; 293(18);6736-6750 [Pubmed: 29530978]
Throughput
- High Throughput
Curated By
- BioGRID