BAIT
YWHAZ
14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SERPINE2
B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4
serine (or cysteine) peptidase inhibitor, clade E, member 2
GO Process (29)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [IMP]
- cerebellar granular layer morphogenesis [IMP]
- dense core granule biogenesis [ISO]
- detection of mechanical stimulus involved in sensory perception [IMP]
- innervation [IMP]
- long-term synaptic potentiation [IMP]
- mating plug formation [IMP]
- negative regulation of blood coagulation [ISO]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of endopeptidase activity [IMP]
- negative regulation of peptidase activity [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IGI]
- negative regulation of plasminogen activation [IMP, ISO]
- negative regulation of platelet activation [IMP]
- negative regulation of platelet aggregation [IMP]
- negative regulation of protein catabolic process [IMP, ISO]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [ISO]
- negative regulation of smoothened signaling pathway [IGI]
- negative regulation of sodium ion transport [IGI, IMP]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of timing of cell differentiation [IMP]
- response to wounding [IMP]
- secretion by cell [IMP, ISO]
- secretory granule organization [IMP, ISO]
- seminal vesicle epithelium development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Elucidation of the 14-3-3? interactome reveals critical roles of RNA-splicing factors during adipogenesis.
Adipogenesis involves a complex signaling network requiring strict temporal and spatial organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate such organization, and we have previously identified 14-3-3? as an essential scaffold in adipocyte differentiation. The interactome of 14-3-3? is large and diverse, and it is possible that novel adipogenic factors may be present within it, but this ... [more]
J. Biol. Chem. Dec. 04, 2017; 293(18);6736-6750 [Pubmed: 29530978]
Throughput
- High Throughput
Curated By
- BioGRID