CACNA1D
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISO]
- aging [IEP]
- calcium ion import [IMP, ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA, ISO]
- calcium-mediated signaling [IDA]
- divalent metal ion transport [IMP]
- heart development [IEP]
- membrane depolarization during SA node cell action potential [ISO]
- membrane depolarization during action potential [IBA]
- membrane depolarization during cardiac muscle cell action potential [IC]
- membrane repolarization during SA node cell action potential [ISO]
- memory [IEP]
- positive regulation of CREB transcription factor activity [IMP]
- positive regulation of calcium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of calcium ion transport [IDA]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of potassium ion transmembrane transport [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA]
- alpha-actinin binding [ISO]
- ankyrin binding [IPI, ISO]
- high voltage-gated calcium channel activity [IDA, IMP, ISO]
- protein binding [IPI]
- voltage-gated calcium channel activity [IDA, ISO]
- voltage-gated calcium channel activity involved SA node cell action potential [ISO]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
- PDZ domain binding [IDA]
- alpha-actinin binding [ISO]
- ankyrin binding [IPI, ISO]
- high voltage-gated calcium channel activity [IDA, IMP, ISO]
- protein binding [IPI]
- voltage-gated calcium channel activity [IDA, ISO]
- voltage-gated calcium channel activity involved SA node cell action potential [ISO]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
Gene Ontology Cellular Component
GABBR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Direct interaction and functional coupling between voltage-gated CaV1.3 Ca2+ channel and GABAB receptor subunit 2.
Although CaV1.2 and CaV1.3 are two subtypes of L-type Ca2+ channels expressed in the CNS, functions of CaV1.3 have not been well elucidated compared to CaV1.2. Here, we found that CaV1.3-NT associates with GABABR2-CT using yeast two-hybrid, GST pull-down and co-immunoprecipitation assays. We also demonstrated co-localization of CaV1.3 and GABABR2 in HEK293 cells and cultured hippocampal neurons. Whole-cell patch-clamp and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CACNA1D GABBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GABBR2 CACNA1D | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CACNA1D GABBR2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID